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156 results

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Page 1
Did you mean tcm and liver (3,052 results)?
Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA.
Liu MC, Oxnard GR, Klein EA, Swanton C, Seiden MV; CCGA Consortium. Liu MC, et al. Ann Oncol. 2020 Jun;31(6):745-759. doi: 10.1016/j.annonc.2020.02.011. Epub 2020 Mar 30. Ann Oncol. 2020. PMID: 33506766 Free PMC article.
Stage I-III sensitivity was 67.3% (CI: 60.7% to 73.3%) in a pre-specified set of 12 cancer types (anus, bladder, colon/rectum, esophagus, head and neck, liver/bile-duct, lung, lymphoma, ovary, pancreas, plasma cell neoplasm, stomach), which account for 63% of US cancer dea …
Stage I-III sensitivity was 67.3% (CI: 60.7% to 73.3%) in a pre-specified set of 12 cancer types (anus, bladder, colon/rectum, esophagus, he …
Liver injury in cynomolgus monkeys following intravenous and intrathecal scAAV9 gene therapy delivery.
Hudry E, Aihara F, Meseck E, Mansfield K, McElroy C, Chand D, Tukov FF, Penraat K. Hudry E, et al. Mol Ther. 2023 Oct 4;31(10):2999-3014. doi: 10.1016/j.ymthe.2023.07.020. Epub 2023 Jul 28. Mol Ther. 2023. PMID: 37515322 Free article.
These transient acute liver injury marker elevations occur from 3-4 days post intravenous administration to 2 weeks post intrathecal administration. ...Co-administration of prednisolone after intravenous or intrathecal dosing did not prevent liver enzyme or microsco …
These transient acute liver injury marker elevations occur from 3-4 days post intravenous administration to 2 weeks post intrathecal …
Metabolic Communication by SGLT2 Inhibition.
Billing AM, Kim YC, Gullaksen S, Schrage B, Raabe J, Hutzfeldt A, Demir F, Kovalenko E, Lassé M, Dugourd A, Fallegger R, Klampe B, Jaegers J, Li Q, Kravtsova O, Crespo-Masip M, Palermo A, Fenton RA, Hoxha E, Blankenberg S, Kirchhof P, Huber TB, Laugesen E, Zeller T, Chrysopoulou M, Saez-Rodriguez J, Magnussen C, Eschenhagen T, Staruschenko A, Siuzdak G, Poulsen PL, Schwab C, Cuello F, Vallon V, Rinschen MM. Billing AM, et al. Circulation. 2024 Mar 12;149(11):860-884. doi: 10.1161/CIRCULATIONAHA.123.065517. Epub 2023 Dec 28. Circulation. 2024. PMID: 38152989 Free PMC article.
RESULTS: Kidneys of nondiabetic mice reacted most strongly to SGLT2i in terms of proteomic reconfiguration, including evidence for less early proximal tubule glucotoxicity and a broad downregulation of the apical uptake transport machinery (including sodium, glucose, urate, purin …
RESULTS: Kidneys of nondiabetic mice reacted most strongly to SGLT2i in terms of proteomic reconfiguration, including evidence for less earl …
TAT-MTS-MCM fusion proteins reduce MMA levels and improve mitochondrial activity and liver function in MCM-deficient cells.
Erlich-Hadad T, Hadad R, Feldman A, Greif H, Lictenstein M, Lorberboum-Galski H. Erlich-Hadad T, et al. J Cell Mol Med. 2018 Mar;22(3):1601-1613. doi: 10.1111/jcmm.13435. Epub 2017 Dec 19. J Cell Mol Med. 2018. PMID: 29265583 Free PMC article.
Liver or combined liver/kidney transplantation has been used to treat those with the most severe clinical manifestations. ...Treatment also enhanced albumin and urea secretion in a CRISPR/Cas9-engineered HepG2 MUT (-/-) liver cell line. Therefore, we suggest …
Liver or combined liver/kidney transplantation has been used to treat those with the most severe clinical manifestations. ...T …
Racial and Ethnic Disparities in Liver Transplantation for Alcohol-associated Liver Diseases in the United States.
Cotter TG, Mitchell MC, Patel MJ, Anouti A, Lieber SR, Rich NE, Arab JP, Díaz LA, Louissaint J, Kerr T, Mufti AR, Hanish SI, Vagefi PA, Patel MS, VanWagner LB, Lee WM, O'Leary JG, Singal AG. Cotter TG, et al. Transplantation. 2024 Jan 1;108(1):225-234. doi: 10.1097/TP.0000000000004701. Epub 2023 Jun 21. Transplantation. 2024. PMID: 37340542
BACKGROUND: Emerging data suggest disparities exist in liver transplantation (LT) for alcohol-associated liver disease (ALD). ...
BACKGROUND: Emerging data suggest disparities exist in liver transplantation (LT) for alcohol-associated liver disease (ALD). …
MCM family in HCC: MCM6 indicates adverse tumor features and poor outcomes and promotes S/G2 cell cycle progression.
Liu Z, Li J, Chen J, Shan Q, Dai H, Xie H, Zhou L, Xu X, Zheng S. Liu Z, et al. BMC Cancer. 2018 Feb 20;18(1):200. doi: 10.1186/s12885-018-4056-8. BMC Cancer. 2018. PMID: 29463213 Free PMC article. Review.
METHODS: MCMs were analyzed in 105 samples including normal livers (n = 15), cirrhotic livers (n = 40), HCC (n = 50) using quantitative polymerase chain reaction (qPCR) (Cohort 1). Significantly up-regulated MCMs were verified in 102 HCC and matched peritumoral l …
METHODS: MCMs were analyzed in 105 samples including normal livers (n = 15), cirrhotic livers (n = 40), HCC (n = 50) using qua …
MCM6 promotes intrahepatic cholangiocarcinoma progression by upregulating E2F1 and enhancing epithelial-mesenchymal transition.
Gao C, Li J, Zeng F, Wang L, Chen K, Chen D, Hong J, Qu C. Gao C, et al. Carcinogenesis. 2023 Jun 24;44(4):279-290. doi: 10.1093/carcin/bgad023. Carcinogenesis. 2023. PMID: 37185675
Minichromosome maintenance complex component 6 (MCM6), a member of the MCM family, plays a pivotal role in DNA replication initiation and genome duplication of proliferating cells. ...
Minichromosome maintenance complex component 6 (MCM6), a member of the MCM family, plays a pivotal role in DNA replication initiation …
Integration of deep learning-based histopathology and transcriptomics reveals key genes associated with fibrogenesis in patients with advanced NASH.
Conway J, Pouryahya M, Gindin Y, Pan DZ, Carrasco-Zevallos OM, Mountain V, Subramanian GM, Montalto MC, Resnick M, Beck AH, Huss RS, Myers RP, Taylor-Weiner A, Wapinski I, Chung C. Conway J, et al. Cell Rep Med. 2023 Apr 18;4(4):101016. doi: 10.1016/j.xcrm.2023.101016. Cell Rep Med. 2023. PMID: 37075704 Free PMC article.
Nonalcoholic steatohepatitis (NASH) is the most common chronic liver disease globally and a leading cause for liver transplantation in the US. ...Notably, the Notch signaling pathway and genes implicated in liver-related diseases were enriched in this express …
Nonalcoholic steatohepatitis (NASH) is the most common chronic liver disease globally and a leading cause for liver transplant …
Identification of MCM family as potential therapeutic and prognostic targets for hepatocellular carcinoma based on bioinformatics and experiments.
Lei Y, Wang S, Liu J, Yan W, Han P, Tian D. Lei Y, et al. Life Sci. 2021 May 1;272:119227. doi: 10.1016/j.lfs.2021.119227. Epub 2021 Feb 16. Life Sci. 2021. PMID: 33607151
AIMS: The minichromosome maintenance (MCM) complex is highly conserved, which has drawn increasing attention on physiology and pathology process. However, the role of MCM in hepatocellular carcinoma (HCC) remains largely unclear. We aimed to conduct systematic analy …
AIMS: The minichromosome maintenance (MCM) complex is highly conserved, which has drawn increasing attention on physiology and pathol …
MCMs in Cancer: Prognostic Potential and Mechanisms.
Yu S, Wang G, Shi Y, Xu H, Zheng Y, Chen Y. Yu S, et al. Anal Cell Pathol (Amst). 2020 Feb 3;2020:3750294. doi: 10.1155/2020/3750294. eCollection 2020. Anal Cell Pathol (Amst). 2020. PMID: 32089988 Free PMC article. Review.
This review provides an overview of the significant findings regarding the cellular and tumorigenic functions of the MCM family. Besides, current evidence of the prognostic roles of MCMs is retrospectively reviewed. This work also offers insight into the mechanisms of MCMs …
This review provides an overview of the significant findings regarding the cellular and tumorigenic functions of the MCM family. Besi …
156 results